Furlan, Chris, Berenbeim, Jacob A. and Dessent, Caroline E.H. orcid.org/0000-0003-4944-0413 (2020) Photoproducts of the Photodynamic Therapy Agent Verteporfin Identified via Laser Interfaced Mass Spectrometry. Molecules (Basel, Switzerland). 5280. ISSN 1420-3049
Abstract
Verteporfin, a free base benzoporphyrin derivative monoacid ring A, is a photosensitizing drug for photodynamic therapy (PDT) used in the treatment of the wet form of macular degeneration and activated by red light of 689 nm. Here, we present the first direct study of its photofragmentation channels in the gas phase, conducted using a laser interfaced mass spectrometer across a broad photoexcitation range from 250 to 790 nm. The photofragmentation channels are compared with the collision-induced dissociation (CID) products revealing similar dissociation pathways characterized by the loss of the carboxyl and ester groups. Complementary solution-phase photolysis experiments indicate that photobleaching occurs in verteporfin in acetonitrile; a notable conclusion, as photoinduced activity in Verteporfin was not thought to occur in homogenous solvent conditions. These results provide unique new information on the thermal break-down products and photoproducts of this light-triggered drug.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 by the authors. |
Keywords: | laser spectroscopy,mass spectrometry,PDT,photo dynamic therapy,photofragmentation channels,photofragments,photolysis,photosensitizer,verteporfin |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 07 Dec 2020 12:20 |
Last Modified: | 20 Dec 2024 00:18 |
Published Version: | https://doi.org/10.3390/molecules25225280 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.3390/molecules25225280 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:168756 |