Delvenne, J-F orcid.org/0000-0002-1990-9738, Scally, B, Bunce, D orcid.org/0000-0003-3265-2700 et al. (1 more author) (2021) Splenium tracts of the corpus callosum degrade in old age. Neuroscience Letters, 742. 135549. ISSN 0304-3940
Abstract
It is well established that the posterior region of the corpus callosum, known as the splenium, is relatively preserved during the course of normal ageing. However, the effect of age on its distinct interhemispheric tract bundles that project to bilateral occipital, parietal and temporal areas of the cortex, is largely unknown. In the present study, diffusion tensor imaging was used to directly examine the integrity of these distinct segregations and their diffusion metrics were compared between groups of young adults (n = 20, mean age = 30.75) and older adults (n = 19, mean age = 80.21). Results revealed that while occipital tracts were preserved in older adults, parietal and temporal segments were particularly impaired. These findings are the first to indicate the existence of selective alterations in the posterior region of the corpus callosum in older age.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Elsevier B.V. All rights reserved. This is an author produced version of an article published in Neuroscience Letters. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Corpus Callosum; Splenium; Diffusion tensor imaging; Ageing |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Psychology (Leeds) |
Funding Information: | Funder Grant number Alzheimer's Research UK ARUK-PPG2014A-19 |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 Dec 2020 12:24 |
Last Modified: | 04 Dec 2021 01:38 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.neulet.2020.135549 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:168732 |