Bottery, Michael J. orcid.org/0000-0001-5790-1756, Pitchford, Jonathan W. orcid.org/0000-0002-8756-0902 and Friman, Ville Petri orcid.org/0000-0002-1592-157X (2020) Ecology and evolution of antimicrobial resistance in bacterial communities. ISME Journal. ISSN 1751-7362
Abstract
Accumulating evidence suggests that the response of bacteria to antibiotics is significantly affected by the presence of other interacting microbes. These interactions are not typically accounted for when determining pathogen sensitivity to antibiotics. In this perspective, we argue that resistance and evolutionary responses to antibiotic treatments should not be considered only a trait of an individual bacteria species but also an emergent property of the microbial community in which pathogens are embedded. We outline how interspecies interactions can affect the responses of individual species and communities to antibiotic treatment, and how these responses could affect the strength of selection, potentially changing the trajectory of resistance evolution. Finally, we identify key areas of future research which will allow for a more complete understanding of antibiotic resistance in bacterial communities. We emphasise that acknowledging the ecological context, i.e. the interactions that occur between pathogens and within communities, could help the development of more efficient and effective antibiotic treatments.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2020 |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Centre for Immunology and Infection (CII) (York) The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Mathematics (York) |
Depositing User: | Pure (York) |
Date Deposited: | 04 Dec 2020 09:50 |
Last Modified: | 27 Dec 2024 00:17 |
Published Version: | https://doi.org/10.1038/s41396-020-00832-7 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1038/s41396-020-00832-7 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:168705 |
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Description: Ecology and evolution of antimicrobial resistance in bacterial communities
Licence: CC-BY 2.5