Allwardt, V, Ainscough, AJ, Viswanathan, P et al. (4 more authors) (2020) Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption. Bioengineering, 7 (3). 112. pp. 1-27. ISSN 2306-5354
Abstract
Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of the drug discovery process; to advance insights into human biology; to enable clinical research where human trials are not feasible. However, further development is needed for the successful adoption and acceptance of this technology. Areas for improvement include technological maturity, more robust validation of translational and predictive in vivo-like biology, and requirements of tighter quality standards for commercial viability. In this review, we reported on the consensus around existing challenges and necessary performance benchmarks that are required toward the broader adoption of OOACs in the next five years, and we defined a potential roadmap for future translational development of OOAC technology. We provided a clear snapshot of the current developmental stage of OOAC commercialization, including existing platforms, ancillary technologies, and tools required for the use of OOAC devices, and analyze their technology readiness levels. Using data gathered from OOAC developers and end-users, we identified prevalent challenges faced by the community, strategic trends and requirements driving OOAC technology development, and existing technological bottlenecks that could be outsourced or leveraged by active collaborations with academia.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) |
Keywords: | organ-on-a-chip; technology-led strategy; gap analysis; validation; translation; quality management; body-on-a-chip; organotypic culture models; microphysiological systems |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Electronic & Electrical Engineering (Leeds) > Pollard Institute (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 27 Nov 2020 16:07 |
Last Modified: | 27 Nov 2020 16:07 |
Status: | Published |
Publisher: | MDPI |
Identification Number: | 10.3390/bioengineering7030112 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:168450 |
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Filename: Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption.pdf
Licence: CC-BY 4.0