Tomeh, M.A. and Zhao, X. orcid.org/0000-0002-4620-2893 (2020) Recent advances in microfluidics for the preparation of drug and gene delivery systems. Molecular Pharmaceutics, 17 (12). pp. 4421-4434. ISSN 1543-8384
Abstract
Drug delivery systems (DDSs) have great potential for improving the treatment of several diseases, especially microbial infections and cancers. However, the formulation procedures of DDSs remain challenging, especially at the nanoscale. Reducing batch-to-batch variation and enhancing production rate are some of the essential requirements for accelerating the translation of DDSs from a small scale to an industrial level. Microfluidic technologies have emerged as an alternative to the conventional bench methods to address these issues. By providing precise control over the fluid flows and rapid mixing, microfluidic systems can be used to fabricate and engineer different types of DDSs with specific properties for efficient delivery of a wide range of drugs and genetic materials. This review discusses the principles of controlled rapid mixing that have been employed in different microfluidic strategies for producing DDSs. Moreover, the impact of the microfluidic device design and parameters on the type and properties of DDS formulations was assessed, and recent applications in drug and gene delivery were also considered.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 American Chemical Society. This is an author-produced version of a paper subsequently published in Molecular Pharmaceutics. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | drug delivery systems; microfluidics; nanomedicine; rapid mixing; tunable properties |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Funding Information: | Funder Grant number Engineering and Physical Sciences Research Council EP/N023579/1; EP/N007174/1; EP/N023579/1 The Royal Society IE150457 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 26 Nov 2020 10:43 |
Last Modified: | 02 Feb 2022 10:35 |
Status: | Published |
Publisher: | American Chemical Society (ACS) |
Refereed: | Yes |
Identification Number: | 10.1021/acs.molpharmaceut.0c00913 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:168435 |