Lichman, Benjamin R. orcid.org/0000-0002-0033-1120 (2021) The scaffold-forming steps of plant alkaloid biosynthesis. NATURAL PRODUCT REPORTS. pp. 103-129. ISSN 0265-0568
Abstract
Alkaloids from plants are characterised by structural diversity and bioactivity, and maintain a privileged position in both modern and traditional medicines. In recent years, there have been significant advances in elucidating the biosynthetic origins of plant alkaloids. In this review, I will describe the progress made in determining the metabolic origins of the so-called true alkaloids, specialised metabolites derived from amino acids containing a nitrogen heterocycle. By identifying key biosynthetic steps that feature in the majority of pathways, I highlight the key roles played by modifications to primary metabolism, iminium reactivity and spontaneous reactions in the molecular and evolutionary origins of these pathways.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Funding Information: The author acknowledges support from a UKRI Future Leaders Fellowship (MR/S01862X/1). Publisher Copyright: © The Royal Society of Chemistry. Copyright: Copyright 2021 Elsevier B.V., All rights reserved. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 19 Nov 2020 12:30 |
Last Modified: | 11 Jan 2025 00:08 |
Published Version: | https://doi.org/10.1039/d0np00031k |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1039/d0np00031k |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:168182 |