Drayton, Alexander, Li, Kezheng, Simmons, Mattrew et al. (2 more authors) (2020) Performance limitations of resonant refractive index sensors with low-cost components. Optics Express. 400236. pp. 32239-32248. ISSN 1094-4087
Abstract
Resonant biosensors are attractive for diagnostics because they can detect clinically relevant biomarkers with high sensitivity and in a label-free fashion. Most of the current solutions determine their detection limits in a highly stabilised laboratory environment, which does, however, not apply to real point-of-care applications. Here, we consider the more realistic scenario of low-cost components and an unstabilised environment and consider the related design implications. We find that sensors with lower quality-factor resonances are more fault tolerant, that a filtered LED lightsource is advantageous compared to a diode laser, and that a CMOS camera is preferable to a CCD camera for detection. We exemplify these findings with a guided mode resonance sensor and experimentally determine a limit of detection of 5.8 ± 1.7×10−5 refractive index units (RIU), which is backed up by a model identifying the various noise sources. Our findings will inform the design of high performance, low cost biosensors capable of operating in a real-world environment.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020, The Author(s). |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Physics (York) |
Depositing User: | Pure (York) |
Date Deposited: | 17 Nov 2020 15:50 |
Last Modified: | 26 Nov 2024 00:48 |
Published Version: | https://doi.org/10.1364/OE.400236 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1364/OE.400236 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:168113 |