Tickner, Benjamin, Ahwal, Fadi, Whitwood, Adrian C. et al. (1 more author) (2020) Reversible hyperpolarization of ketoisocaproate using sulfoxide-containing polarization transfer catalysts. ChemPhysChem. 202000825R1. ISSN 1439-4235
Abstract
The substrate scope of sulfoxide-containing magnetisation transfer catalysts is extended to hyperpolarize α-ketoisocaproate and α-ketoisocaproate-1-[13C]. This is achieved by forming [Ir(H)2(κ2-ketoisocaproate)(N-heterocyclic carbene)(sulfoxide)] which transfers latent magnetism from p-H2 via the signal amplification by reversible exchange (SABRE) process. The effect of polarization transfer field on the formation of enhanced 13C magnetization is evaluated. Consequently, performing SABRE in a 0.5 µT field enabled most efficient magnetisation transfer. 13C NMR signals for α-ketoisocaproate-1-[13C] in methanol-d4 are up to 985-fold more intense than their traditional Boltzmann derived signal intensity (0.8% 13C polarisation). Single crystal X-ray diffraction reveals the formation of the novel catalyst decomposition products [Ir(µ-H)(H)2(IMes)(SO(Ph)(Me)2)]2 and [(Ir(H)2(IMes)(SO(Me)2))2(µ-S)] when the sulfoxides methylphenylsulfoxide and dimethylsulfoxide are used respectively.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The Authors |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number MEDICAL RESEARCH COUNCIL (MRC) MR/M008991/1 WELLCOME TRUST 098335/Z/12/Z |
Depositing User: | Pure (York) |
Date Deposited: | 11 Nov 2020 10:40 |
Last Modified: | 04 Nov 2024 01:24 |
Published Version: | https://doi.org/10.1002/cphc.202000825 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1002/cphc.202000825 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:167874 |
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Filename: cphc.202000825.pdf
Description: Reversible Hyperpolarization of Ketoisocaproate Using Sulfoxide‐containing Polarization Transfer Catalysts
Licence: CC-BY 2.5