Collier, G. orcid.org/0000-0002-1874-4775, Eaden, J., Hughes, P. et al. (6 more authors) (2021) Dissolved 129Xe lung MRI with four‐echo 3D radial spectroscopic imaging: quantification of regional gas transfer in idiopathic pulmonary fibrosis. Magnetic Resonance in Medicine, 85 (5). pp. 2622-2633. ISSN 0740-3194
Abstract
Purpose Imaging of the different resonances of dissolved hyperpolarized xenon‐129 (129Xe) in the lung is performed using a four‐echo flyback 3D radial spectroscopic imaging technique and is evaluated in healthy volunteers (HV) and subjects with idiopathic pulmonary fibrosis (IPF).
Theory and Methods 10 HV and 25 subjects with IPF underwent dissolved 129Xe MRI at 1.5T. IPF subjects underwent same day pulmonary function tests to measure forced vital capacity and the diffusion capacity of the lung for carbon monoxide (DLCO). A four‐point echo time technique with k‐space chemical‐shift modeling of gas, dissolved 129Xe in lung tissue/plasma (TP) and red blood cells (RBC) combined with a 3D radial trajectory was implemented within a 14‐s breath‐hold.
Results Results show an excellent chemical shift separation of the dissolved 129Xe compartments and gas contamination removal, confirmed by a strong agreement between average imaging and global spectroscopy RBC/TP ratio measurements. Subjects with IPF exhibited reduced imaging gas transfer when compared to HV. A significant increase of the amplitude of RBC signal cardiogenic oscillation was also observed. In IPF subjects, DLCO% predicted was significantly correlated with RBC/TP and RBC/GAS ratios and the correlations were stronger in the inferior and periphery sections of the lungs.
Conclusion Lung MRI of dissolved 129Xe was performed with a four‐echo spectroscopic imaging method. Subjects with IPF demonstrated reduced xenon imaging gas transfer and increased cardiogenic modulation of dissolved xenon signal in the RBCs when compared to HV.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 International Society for Magnetic Resonance in Medicine. This is an author-produced version of a paper subsequently published in Magnetic Resonance in Medicine. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | hyperpolarized 129Xe; Lung; IPF; spectroscopic imaging |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Infection and Immunity (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 09 Nov 2020 13:45 |
Last Modified: | 02 Feb 2022 08:20 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/mrm.28609 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:167789 |