Pitruzzello, Giampaolo, Conteduca, Donato and Krauss, Thomas F. orcid.org/0000-0003-4367-6601 (2020) Nanophotonics for bacterial detection and antimicrobial susceptibility testing. Nanophotonics. ISSN 2192-8614
Abstract
Photonic biosensors are a major topic of research that continues to make exciting advances. Technology has now improved sufficiently for photonics to enter the realm of microbiology and to allow for the detection of individual bacteria. Here, we discuss the different nanophotonic modalities used in this context and highlight the opportunities they offer for studying bacteria. We critically review examples from the recent literature, starting with an overview of photonic devices for the detection of bacteria, followed by a specific analysis of photonic antimicrobial susceptibility tests. We show that the intrinsic advantage of matching the optical probed volume to that of a single, or a few, bacterial cell, affords improved sensitivity while providing additional insight into single-cell properties. We illustrate our argument by comparing traditional culture-based methods, which we term macroscopic, to microscopic free-space optics and nanoscopic guided-wave optics techniques. Particular attention is devoted to this last class by discussing structures such as photonic crystal cavities, plasmonic nanostructures and interferometric configurations. These structures and associated measurement modalities are assessed in terms of limit of detection, response time and ease of implementation. Existing challenges and issues yet to be addressed will be examined and critically discussed.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Giampaolo Pitruzzello et al., published by De Gruyter, Berlin/Boston. |
Keywords: | antimicrobial resistance,bacteria,evanescent-wave sensing,photonic biosensors |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > York Institute for Materials Research The University of York > Faculty of Sciences (York) > Physics (York) |
Depositing User: | Pure (York) |
Date Deposited: | 05 Nov 2020 15:20 |
Last Modified: | 21 Jan 2025 17:50 |
Published Version: | https://doi.org/10.1515/nanoph-2020-0388 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1515/nanoph-2020-0388 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:167692 |
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Description: [21928614 - Nanophotonics] Nanophotonics for bacterial detection and antimicrobial susceptibility testing
Licence: CC-BY 2.5