Newham, G orcid.org/0000-0002-4877-5513, Mathew, RK orcid.org/0000-0002-2609-9876, Wurdak, H orcid.org/0000-0003-4385-4324 et al. (2 more authors) (2021) Polyelectrolyte Complex Templated Synthesis of Monodisperse, Sub-100 nm Porous Silica Nanoparticles for Cancer Targeted and Stimuli-Responsive Drug Delivery. Journal of Colloid and Interface Science, 584. pp. 669-683. ISSN 0021-9797
Abstract
Porous silica nanoparticles (PSiNPs) have long attracted interest in drug delivery research. However, conventional synthesis methods for sub-100 nm, functionalised PSiNPs typically give poor monodispersity, reproducibility, or involve complex synthetic protocols. We report a facile, reproducible, and cost-effective one-pot method for the synthesis of cancer targeting and pH responsive PSiNPs in this size range, without the need for post-synthetic modification. This was achieved by using monodisperse L-arginine (Arg)/ poly(acrylic acid) (PAA) polyelectrolyte complexes (PECs) as soft templates for silane hydrolysis and condensation. Highly uniform PSiNPs with tunable size control between 42 and 178 nm and disordered pore structure (1.1–2.7 nm) were obtained. Both PAA and Arg were retained within the PSiNPs, which enabled a high doxorubicin hydrochloride (Dox) loading capacity (22% w/w) and a 4-fold increase in drug release under weakly acidic pH compared to physiological pH. The surface presentation of Arg conferred significantly higher intracellular accumulation of Arg/PAA-PSiNPs in patient-derived glioblastoma cells compared to non-tumorigenic neural progenitor cells, which effectively translated to lower IC50 values for Dox-loaded Arg/PAA-PSiNPs than non-functionalised PSiNPs. This work brings forward new insights for the development of monodisperse PSiNPs with highly desirable built-in functionalities for biomedical applications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The Authors. Published by Elsevier Inc. This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited: https://creativecommons.org/licenses/by/4.0/ |
Keywords: | Porous silica nanoparticle; Polyelectrolyte complex; Cancer targeting; Drug delivery; Glioblastoma |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Physics and Astronomy (Leeds) > Molecular & Nanoscale Physics |
Funding Information: | Funder Grant number EPSRC (Engineering and Physical Sciences Research Council) EP/P023266/1 Candlelighters Not Known Yorkshire's Brain Tumour Charity was Brain Tumour Res & Support ax Yorks Not Known |
Depositing User: | Symplectic Publications |
Date Deposited: | 05 Nov 2020 09:35 |
Last Modified: | 02 Jan 2025 11:20 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jcis.2020.10.133 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:167480 |