Schini, M. orcid.org/0000-0003-2204-2095, Jacques, R. orcid.org/0000-0001-6710-5403, Oakes, E. et al. (3 more authors) (2021) Normocalcaemic hyperparathyroidism (NPHPT) and primary hyperparathyroidism (PHPT): Least significant change (LSC) for adjusted serum calcium. European Journal of Endocrinology, 184 (1). K7-K10. ISSN 0804-4643
Abstract
Introduction: The least significant change (LSC) is a term used in individuals in order to evaluate whether one measurement has changed significantly from the previous one. It is widely used when assessing bone mineral density (BMD) scans. To the best of our knowledge, there no such estimate available in the literature for patients with disorders of calcium metabolism. Our aim was to provide an estimate of the least significant change for albumin-adjusted calcium in patients with normocalcaemic hyperparathyroidism (NPHPT) and primary hyperparathyroidism (PHPT).
Methods: We used the within subject standard deviation calculated in a population of NPHPT and PHPT patients and multiplied it by 2.77.
Results: The LSC for NPHPT and PHPT were found to be 0.25 and 0.24 mmol/L respectively (1.00 and 0.96 mg/dL). In clinical practice, the value of 0.25 mmol/L could be used.
Discussion: The least significant change given, could be used in two ways in these patients. First, it gives a range to which values are expected. This can provide some reassurance for the patient and the physician in cases of intermittent hypercalcaemia. Moreover, it can be a marker of whether an individual has an actual significant change of his calcium after parathyroid surgery.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License.(http://creativecommons.org/licenses/by/4.0) |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 04 Nov 2020 14:23 |
Last Modified: | 02 Dec 2020 12:08 |
Status: | Published |
Publisher: | Bioscientifica |
Refereed: | Yes |
Identification Number: | 10.1530/eje-20-0634 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:167432 |