Harrington, Marcus Oliver, Ashton, Jennifer, Ngo, Hong-Viet et al. (1 more author) (2021) Phase-locked Auditory Stimulation of Theta Oscillations during Rapid Eye Movement Sleep. Sleep. zsaa227. ISSN 1550-9109
Abstract
Auditory closed-loop stimulation is a non-invasive technique that has been widely used to augment slow oscillations during non-rapid eye movement sleep. Based on the principles of closed-loop stimulation, we developed a novel protocol for manipulating theta activity (3-7 Hz) in rapid eye movement (REM) sleep. Sixteen healthy young adults were studied in two overnight conditions: Stimulation and Sham. In the Stimulation condition, 1 s of 5 Hz amplitude-modulated white noise was delivered upon detection of two supra-threshold theta cycles throughout REM sleep. In the Sham condition, corresponding time points were marked but no stimulation was delivered. Auditory stimulation entrained EEG activity to 5 Hz and evoked a brief (~0.5 s) increase in theta power. Interestingly, this initial theta surge was immediately followed by a prolonged (~3 s) period of theta suppression. Stimulation also induced a prolonged (~2 s) increase in beta power. Our results provide the first demonstration that the REM sleep theta rhythm can be manipulated in a targeted manner via auditory stimulation. Accordingly, auditory stimulation might offer a fruitful avenue for investigating REM sleep electrophysiology and its relationship to behaviour.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Psychology (York) |
Funding Information: | Funder Grant number MEDICAL RESEARCH COUNCIL (MRC) UNSPECIFIED MEDICAL RESEARCH COUNCIL (MRC) MR/P020208/1 |
Depositing User: | Pure (York) |
Date Deposited: | 30 Oct 2020 10:30 |
Last Modified: | 23 Jan 2025 00:24 |
Published Version: | https://doi.org/10.1093/sleep/zsaa227 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1093/sleep/zsaa227 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:167373 |
Download
Filename: Harrington_Manuscript_R2_Clean.docx
Description: Harrington_Manuscript_R2_Clean