Alsirawan, MHDB, Lai, X, Prohens, R et al. (5 more authors) (2020) Mechanistic Understanding of Competitive Destabilization of Carbamazepine Cocrystals under Solvent Free Conditions. Crystal Growth & Design, 20 (9). pp. 6024-6029. ISSN 1528-7483
Abstract
Mechanistic understanding of competitive destabilization of carbamazepine:nicotinamide and carbamazepine:saccharin cocrystals under solvent free conditions has been investigated. The crystal phase transformations were monitored using hot stage microscopy, variable-temperature powder X-ray diffraction, and sublimation experiments. The destabilization of the two cocrystals occurs via two distinct mechanisms: vapor and eutectic phase formations. Vapor pressure measurements and thermodynamic calculations using fusion and sublimation enthalpies were in good agreement with experimental findings. The mechanistic understanding is important to maintain the stability of cocrystals during solvent free green manufacturing.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2020 American Chemical Society. This is an author-accepted version of an article published in Crystal Growth & Design. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 02 Nov 2020 20:13 |
Last Modified: | 31 Jul 2021 00:38 |
Status: | Published |
Publisher: | American Chemical Society (ACS) |
Identification Number: | 10.1021/acs.cgd.0c00735 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:167284 |