Sharif, K, Bridgewood, C, Dubash, S et al. (1 more author) (2020) Intestinal and enthesis innate immunity in early axial spondyloarthropathy. Rheumatology, 59 (Supplement_4). iv67-iv78. ISSN 1462-0324
Abstract
Axial SpA (axSpA), encompassing AS, is a multifactorial disease that localizes to sites of high spinal biomechanical stress. Much has been written on T cells and adaptive immunity in axSpA, which is understandable given the very strong HLA-B27 disease association. Extra-axial disease characteristically involves the anterior uveal tract, aortic root, lung apex and terminal ileum. Under recent classification, axSpA is classified as an intermediate between autoimmunity and autoinflammatory disease, with the latter term being synonymous with innate immune dysregulation. The purpose of this review is to evaluate the ‘danger signals’ from both the exogenous intestinal microbiotal adjuvants or pathogen-associated molecular patterns that access the circulation and endogenously derived damaged self-tissue or damage-associated molecular patterns derived from entheses and other sites of high biomechanical stress or damage that may serve as key drivers of axSpA onset, evolution, disease flares and eventual outcomes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | C The Author(s) 2020. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
Keywords: | danger signals; pathogen-associated molecular patterns (PAMPs); damage-associated molecular patterns (DAMPs); axial spondyloarthritis (axSpA); enthesitis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 28 Oct 2020 12:24 |
Last Modified: | 25 Jun 2023 22:28 |
Status: | Published |
Publisher: | Oxford University Press (OUP) |
Identification Number: | 10.1093/rheumatology/keaa408 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:167186 |