Bustamante, Leyla Y, Powell, Gareth T, Lin, Yen-Chun et al. (14 more authors) (2017) Synergistic malaria vaccine combinations identified by systematic antigen screening. Proceedings of the National Academy of Sciences USA. pp. 12045-12050. ISSN 1091-6490
Abstract
A highly effective vaccine would be a valuable weapon in the drive toward malaria elimination. No such vaccine currently exists, and only a handful of the hundreds of potential candidates in the parasite genome have been evaluated. In this study, we systematically evaluated 29 antigens likely to be involved in erythrocyte invasion, an essential developmental stage during which the malaria parasite is vulnerable to antibody-mediated inhibition. Testing antigens alone and in combination identified several strain-transcending targets that had synergistic combinatorial effects in vitro, while studies in an endemic population revealed that combinations of the same antigens were associated with protection from febrile malaria. Video microscopy established that the most effective combinations targeted multiple discrete stages of invasion, suggesting a mechanistic explanation for synergy. Overall, this study both identifies specific antigen combinations for high-priority clinical testing and establishes a generalizable approach that is more likely to produce effective vaccines. Copyright © 2017 the Author(s). Published by PNAS.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | first & last 3 (QQ only),first & last (all papers) |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Depositing User: | Pure (York) |
Date Deposited: | 19 Oct 2020 16:00 |
Last Modified: | 08 Feb 2025 00:39 |
Published Version: | https://doi.org/10.1073/pnas.1702944114 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1073/pnas.1702944114 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:166888 |