Booth, Rosalind, Grogan, Gideon James orcid.org/0000-0003-1383-7056, Wilson, Keith Sanderson orcid.org/0000-0002-3581-2194 et al. (1 more author) (2020) Artificial Imine Reductases: Developments and Future Directions. RSC Chemical Biology. pp. 1-10. ISSN 2633-0679
Abstract
Biocatalytic imine reduction has been a topic of intense research by the artificial metalloenzyme community in recent years. Artificial constructs, together with natural enzymes, have been engineered to produce chiral amines with high enantioselectivity. This review examines the design of the main classes of artificial imine reductases reported thus far and summarises approaches to enhancing their catalytic performance using complementary methods. Examples of utilising these biocatalysts in vivo or in multi-enzyme cascades have demonstrated the potential that artIREDs can offer, however, at this time their use in biocatalysis remains limited. This review explores the current scope of artIREDs and the strategies used for catalyst improvement, and examines the potential for artIREDs in the future.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020, The Author(s). |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number EPSRC EP/L024829/1 UNSPECIFIED EP/T007338/1 |
Depositing User: | Pure (York) |
Date Deposited: | 19 Oct 2020 11:00 |
Last Modified: | 21 Jan 2025 17:49 |
Published Version: | https://doi.org/10.1039/D0CB00113A |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1039/D0CB00113A |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:166853 |