Gilani, SSA, Nair, N, Plant, D et al. (8 more authors) (2020) Pharmacogenetics of TNFi Response in Rheumatoid Arthritis Utilising the Two-Component Disease Activity Score. The Pharmacogenomics Journal, 21 (16). ISSN 1470-269X
Abstract
Aim: TNF inhibitor drugs are a treatment option for rheumatoid arthritis, but response is not universal. Response is typically measured using the composite 4-component (4C) disease activity score 28 (DAS28) which contains more subjective measures. This study used a validated 2-component (2C) DAS28 score to determine whether SNPs associated with response were replicated in the UK population. Materials & methods: A literature review identified TNF inhibitor response SNPs. Linear regression was conducted to replicate associations with 4C or 2C-DAS28 response. Results: Eighteen independent SNPs were analyzed in 1828 patients. One and four associations with 4C and 2C-DAS28 response respectively were identified (p ≤ 0.05). Conclusion: Further genetic associations were replicated using the 2C-DAS28 which may reflect the objective nature of 2C-AS28.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The University of Manchester. This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0. |
Keywords: | biomarker; rheumatoid arthritis; single nucleotide polymorphism; TNF inhibitors; treatment response |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Funding Information: | Funder Grant number MRC (Medical Research Council) R116825 NIHR National Inst Health Research BRC |
Depositing User: | Symplectic Publications |
Date Deposited: | 19 Oct 2020 10:02 |
Last Modified: | 25 Jun 2023 22:28 |
Status: | Published |
Publisher: | Springer Nature |
Identification Number: | 10.2217/pgs-2020-0043 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:166807 |