Cook, A.W. and Toseland, C.P. orcid.org/0000-0002-1641-7535 (2021) The roles of nuclear myosin in the DNA damage response. The Journal of Biochemistry, 169 (3). pp. 265-271. ISSN 0021-924X
Abstract
Myosin within the nucleus has often been overlooked due to their importance in cytoplasmic processes and a lack of investigation. However, more recently it has been shown that their nuclear roles are just as fundamental to cell function and survival with roles in transcription, DNA damage and viral replication. Myosins can act as molecular transporters and anchors that rely on their actin binding and ATPase capabilities. Their roles within the DNA damage response can varies from a transcriptional response, moving chromatin and stabilising chromosome contacts. This review aims to highlight their key roles in the DNA damage response and how they impact nuclear organisation and transcription.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2020. Published by Oxford University Press on behalf of the Japanese Biochemical Society. |
Keywords: | Actin; Damage; DNA; Myosin; Nucleus |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Human Metabolism (Sheffield) The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Oncology (Sheffield) |
Funding Information: | Funder Grant number Medical Research Council MR/M020606/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 16 Oct 2020 12:51 |
Last Modified: | 02 Feb 2022 11:09 |
Status: | Published |
Publisher: | Oxford University Press (OUP) |
Refereed: | Yes |
Identification Number: | 10.1093/jb/mvaa113 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:166789 |