Shimizu, Seishi orcid.org/0000-0002-7853-1683 and Matubayasi, Nobuyuki (2021) Phase stability condition and liquid-liquid phase separation under mesoscale confinement. Physica A: Statistical Mechanics and its Applications. 125385. ISSN 0378-4371
Abstract
Here we establish the thermodynamic phase stability condition under mesoscale confinement, which is essential in elucidating how the confinement of solutions inside a droplet, cell or liposome may influence phase separation. To clarify how phase stability is affected by external conditions, a formal analogy between the partially open ensemble and mesoscopic system will be exploited, through which the nonnegligible role of the system boundary will be identified as the crucial difference from the macroscopic stability condition. The thermodynamic stability condition extended for mesoscale is shown to involve several different orders of magnitude that are all considered to be O(1) at a macroscopic limit. Phase instability in mesoscale is shown to ensue when the difference between self-association (relative self-fluctuation of particle number) and mutual association (relative number correlation between different species) reaches the mesoscopic order of magnitude, in contrast to the divergence of particle number fluctuation (namely, reaching a macroscopic order of magnitude) required in macroscale. Thus, confinement may enhance phase instability.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Elsevier B.V. All rights reserved. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 06 Oct 2020 11:00 |
Last Modified: | 16 Oct 2024 16:22 |
Published Version: | https://doi.org/10.1016/j.physa.2020.125385 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.physa.2020.125385 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:166344 |
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