Jones, Katherine orcid.org/0000-0003-0615-8442, Baker, Katherine, Speight, R. Ally et al. (2 more authors) (2020) Randomised clinical trial:Combined impact and resistance training in adults with stable Crohn’s disease. Alimentary pharmacology & therapeutics. pp. 964-975. ISSN 1365-2036
Abstract
Background: Crohn's disease (CD) is a predisposing factor for bone loss and muscle dysfunction, which could lead to osteoporotic fractures and physical disability, respectively. Aim: To assess the effect of 6 months of combined impact and resistance training on bone mineral density (BMD) and muscle function in adults with CD. Methods: In this randomised controlled trial, 47 adults with stable CD were assigned to exercise (n = 23) or control (n = 24) groups and followed up for 6 months. The exercise group received usual care plus a 6-month combined impact and resistance training programme, involving three, 60-minute sessions per week and a gradual tapering of supervision to self-management. The control group received usual care alone. The primary outcomes were BMD (via dual energy X-ray absorptiometry) and muscle function (measures of upper and lower limb strength and endurance) at 6 months. Results: At 6 months, BMD values were superior in the exercise group with statistical significance at lumbar spine (adjusted mean difference 0.036 g/cm2 , 95% CI 0.024-0.048; P < 0.001), but not at femoral neck (0.018 g/cm2 , 0.001-0.035; P = 0.059) or greater trochanter (0.013 g/cm2, −0.019 to 0.045; P = 0.415) after correcting for multiple outcomes. The exercise group also had superior values for all muscle function outcomes (P < 0.001; unadjusted mean differences ranging 22.6‒48.2%), and lower fatigue severity (P = 0.005). Three exercise-related adverse events were recorded: two instances of light-headedness and one of nausea. Conclusions: The intervention improved BMD and muscle function in adults with CD and appears as a suitable model of exercise for reducing future risk of osteoporotic fractures and disability. Trial registration: ISRCTN11470370.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The Authors. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 05 Oct 2020 13:30 |
Last Modified: | 16 Oct 2024 16:59 |
Published Version: | https://doi.org/DOI: 10.1111/apt.16002 |
Status: | Published |
Refereed: | Yes |
Identification Number: | DOI: 10.1111/apt.16002 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:166290 |