Herbert, J, Edwards, K and Sridharan, V orcid.org/0000-0001-6389-0432 (2020) Palladium catalysed, three-component cascade reaction for the efficient synthesis of diverse small molecules. Tetrahedron Letters, 61 (46). 152536. ISSN 0040-4039
Abstract
A palladium catalysed, three-component cascade reaction was employed for the regiospecific and stereoselective synthesis of novel substituted (Z)-2-butene 1,4-diamine analogues and substituted 4-aryloxy but-2-enyl amine analogues. Allenes were first synthesised from the corresponding alkynes using the Crabbé reaction and then reacted with a large range of commercially available aryl iodides and amines to generate a library of small molecules. The reaction is compatible with aryl iodides containing both electron-donating and electron-withdrawing groups. Amines of different sizes can also be utilised with no noticeable effect on the yield, regiospecificity or stereoselectivity.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Elsevier Ltd. All rights reserved. This is an author produced version of an article published in Tetrahedron Letters. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Palladium; Multicomponent; Allene; Crabbé reaction; 2-Butene-1,4-diamine |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 05 Oct 2020 12:12 |
Last Modified: | 08 Oct 2021 00:38 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.tetlet.2020.152536 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:166258 |