Raynal, Laetitia, Rose, Nicholas C, Donald, James R orcid.org/0000-0002-2176-4902 et al. (1 more author) (2020) Photochemical Methods for Peptide Macrocylization. Chemistry : A European Journal. ISSN 1521-3765
Abstract
Photochemical reactions have been the subject of renewed interest over the last two decades, leading to the development of many new diverse and powerful chemical transformations. More recently, these developments have been expanded to enable the photochemical macrocylization of peptides and small proteins. These constructs benefit from increased stability, structural rigidity, and biological potency over their linear counterparts, providing opportunities for improved therapeutic agents. In this review, we provide an overview of both the established and emerging methods for photochemical peptide macrocyclization, highlighting both the limitations and opportunities for further innovation in the field.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2020, The Author(s). |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 23 Sep 2020 07:50 |
Last Modified: | 26 Nov 2024 00:48 |
Published Version: | https://doi.org/10.1002/chem.202003779 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1002/chem.202003779 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:165878 |