Smith, L orcid.org/0000-0002-4280-6323, Downing, A orcid.org/0000-0002-0335-7801, Norman, P orcid.org/0000-0002-6211-1625 et al. (12 more authors) (2020) Influence of deprivation and rurality on patient-reported outcomes of men living with and beyond prostate cancer diagnosis in the UK: a population-based study. Cancer Epidemiology, 69. 101830. ISSN 1877-7821
Abstract
Background
In the UK, inequalities exist in prostate cancer incidence, survival and treatment by area deprivation and rurality. This work aimed to identify variation in patient-reported outcomes of men with prostate cancer by area type.
Methods
A population-based survey of men 18–42 months after prostate cancer diagnosis (N = 35608) measured self-assessed health (SAH) using the EQ-5D and five functional domains using the Expanded Prostate Cancer Index Composite (EPIC-26).
Results
Mean SAH was higher for men in least deprived areas compared to most deprived (difference 6.3 (95 %CI 5.6–7.2)). SAH scores were lower for men in most urban areas compared to most rural (difference 2.4 (95 %CI 1.8–3.0)). Equivalent estimates in the general population reported a 13 point difference by deprivation and a 4 point difference by rurality. For each EPIC-26 domain, functional outcomes were better for men in the least deprived areas, with clinically meaningful differences observed for urinary incontinence and hormonal function. There were no clinically meaningful differences in EPIC-26 outcomes by rurality with less than a three point difference in scores for each domain between urban and rural areas.
Conclusion
In men 18–42 months post diagnosis of prostate cancer in the UK, impacts of area deprivation and rurality on self-assessed health related quality of life were not greater than would be expected in the general population. However, clinically meaningful differences were identified for some prostate functional outcomes (urinary and hormonal function) by deprivation. No impact by rurality of residence was identified.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020, Elsevier Ltd. All rights reserved. This is an author produced version of an article published in Cancer Epidemiology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Prostate cancer; Deprivation; Rurality; Inequalities; Health-related quality of life; Functional outcomes |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Geography (Leeds) > Centre for Spatial Analysis & Policy (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Clinical Cancer Research (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Health Sciences (Leeds) > Academic Unit of Health Economics (Leeds) |
Funding Information: | Funder Grant number Prostate Cancer UK PROMS |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 Sep 2020 13:58 |
Last Modified: | 28 Sep 2021 00:38 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.canep.2020.101830 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:165740 |
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