A practical experiment to teach students continuous flow and physico-chemical methods: acetylation of ethylene diamine in liquid bi-phase

Abstract

Despite growing applications being reported both in academia and industry, continuous flow chemistry remains a relatively untaught field across most chemistry undergraduate courses. This is particularly true in laboratory practical classes, where it is often deemed simpler to carry out synthetic reactions in traditional batch mode using round-bottomed flasks. Herein, we report the development of an undergraduate project that utilises cheap and readily available materials to construct continuous flow reactors. The students compare the performance of different types of reactors and conditions in a biphasic selective acetylation of a symmetrical diamine. Throughout the investigation, the students can vary multiple parameters as they optimise the reaction, thus actively learning and readjusting them based on their improved understanding. The experiments give the students an appreciation of continuous flow techniques in comparison to batch.

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Item Type:	Article
Authors/Creators:	Bayana, M https://orcid.org/0000-0001-9613-2937 Blacker, AJ https://orcid.org/0000-0003-4898-2712 Clayton, AD https://orcid.org/0000-0002-4634-8008 Jolley, KE Labes, R https://orcid.org/0000-0003-4001-0775 Taylor, CJ Reynolds, W
Copyright, Publisher and Additional Information:	© The Author(s) 2020.This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords:	Undergraduate laboratory practical; Continuous flow methodology; Multiphase flow reactor; Diamine acetylation
Dates:	Accepted: 26 August 2020 Published (online): 11 September 2020 Published: March 2021
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	21 Sep 2020 13:33
Last Modified:	25 Jun 2023 22:25
Status:	Published
Publisher:	Springer
Identification Number:	10.1007/s41981-020-00114-5
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:165699

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A practical experiment to teach students continuous flow and physico-chemical methods: acetylation of ethylene diamine in liquid bi-phase

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