Amabebe, E. orcid.org/0000-0002-3924-5270, Robert, F.O. and Obika, L.F.O. (2017) Osmoregulatory adaptations during lactation : thirst, arginine vasopressin and plasma osmolality responses. Nigerian Journal of Physiological Sciences, 32 (2). pp. 109-116. ISSN 0794-859X
Abstract
Pregnancy and lactation are accompanied by an increase in circulating blood volume secondary to a 10 mOsmol/kgH20 decrease in plasma osmolality, decrease in the osmotic threshold for thirst and arginine vasopressin (AVP) release, prolactin-induced AVP, oxytocin and aldosterone release, as well as increased water intake and retention. The increased blood volume as a result of increased thirst; drinking and fluid retention could be beneficial for milk production and secretion during lactation. Furthermore, AVP can directly initiate milk ejection similar to oxytocin by interacting with both vasopressin and oxytocin receptors located in myoepithelial cells of the mammary gland. This review explores how osmotic equilibrium is maintained during lactation through changes in thirst, AVP release and plasma osmolality; and highlights the potential role of AVP in milk secretion.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Physiological Society of Nigeria. |
Keywords: | Animals; Arginine Vasopressin; Drinking; Humans; Lactation; Osmolar Concentration; Saline Solution, Hypertonic; Water-Electrolyte Balance |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 06 Oct 2020 13:02 |
Last Modified: | 06 Oct 2020 13:02 |
Published Version: | http://www.bioline.org.br/abstract?np17017 |
Status: | Published |
Publisher: | Physiological Society of Nigeria |
Refereed: | Yes |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:165573 |