Mott, Andrew James orcid.org/0000-0001-7844-9033, Mitchell, Alex Steven orcid.org/0000-0001-9311-2092, McDaid, Catriona Maria orcid.org/0000-0002-3751-7260 et al. (6 more authors) (2020) Systematic review assessing the evidence for the use of stem cells in fracture healing. The Bone and Joint journal. pp. 1-2. ISSN 2049-4394
Abstract
Background Bone demonstrates good healing capacity, with a variety of strategies being utilised to enhance this healing. One potential strategy that has been suggested is the use of stem cells to accelerate healing. Objectives Identify and assess the current evidence for the use of stem cells in fracture healing, focussing on the intervention procedure and outcome measurement. Data Sources MEDLINE, CENTRAL, EMBASE, Cochrane Database of Systematic Reviews, WHO-ICTRP, ClinicalTrials.gov, and reference checking of included studies. Study Eligibility Criteria Population: Any adults who have sustained a fracture, not including those with pre-existing bone defects. Intervention: Use of stem cells from any source in the fracture site by any mechanism. Control: Fracture healing without the use of stem cells. Studies without a comparator were also included. Outcome: Any reported outcomes. Study design: Randomised Controlled Trials (RCTs), non-randomised or observational studies, and case series. Synthesis Ninety-four eligible studies were identified. The clinical and methodological aspects of the studies were too heterogeneous for a meta-analysis to be undertaken. A narrative synthesis examined study characteristics, stem cell methods (source, aspiration, concentration, application) and outcomes. Conclusions: Insufficient high-quality evidence is available to determine the efficacy of stem cells for fracture healing. The studies were heterogeneous in population, methods, and outcomes. Work to address these issues and establish standards for future research should be undertaken. Registration ID: CRD42019142041
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Author(s) et al. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 09 Sep 2020 15:00 |
Last Modified: | 28 Nov 2024 00:32 |
Status: | Published online |
Refereed: | Yes |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:165229 |
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