Francis, D, Nelson, A orcid.org/0000-0003-3886-363X and Marsden, S orcid.org/0000-0002-2723-8954 (2020) Synthesis of β‐Diamine Building Blocks by Photocatalytic Hydroamination of Enecarbamates with Amines, Ammonia and N‐H Heterocycles. Chemistry – A European Journal, 26 (65). pp. 14861-14865. ISSN 0947-6539
Abstract
3‐Amino‐substituted saturated nitrogen heterocycles are an important subclass of β‐diamines, appearing in a number of clinical agents. Herein we report a unified approach to these products based upon the regioselective photoredox‐mediated hydroamination of enecarbamates. The amine coupling partner can encompass diverse amine types under a single set of reaction conditions, including primary alkyl amines, ammonia, aryl and heteroaryl amines, and N‐H heterocycles. The method enables the synthesis of a wide range of pharmaceutically‐relevant building blocks.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The Authors. Published by Wiley-VCH GmbH This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | ammonia; (hetero)aromatic amine ; hydroamination ; medicinal chemistry toolkit; N-H heterocycles |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Sep 2020 14:46 |
Last Modified: | 19 Jul 2022 11:29 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/chem.202003562 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:165193 |