Ritzau-Reid, Kaja I., Spicer, Christopher D. orcid.org/0000-0001-8787-578X, Gelmi, Amy et al. (7 more authors) (2020) An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering. ADVANCED FUNCTIONAL MATERIALS. ISSN 1616-301X
Abstract
The unique electrochemical properties of the conductive polymer poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, the functionality of PEDOT:PSS for neural tissue engineering is improved by incorporating 3,4-ethylenedioxythiophene (EDOT) oligomers, synthesized using a novel end-capping strategy, into block co-polymers. By exploiting end-functionalized oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone), a block co-polymer is produced that is electroactive, processable, and bio-compatible. By combining these properties, electroactive fibrous mats are produced for neuronal culture via solution electrospinning and melt electrospinning writing. Importantly, it is also shown that neurite length and branching of neural stem cells can be enhanced on the materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | ©The Authors. Published by Wiley-VCH GmbH. |
Keywords: | 3,4-ethylenedioxythiophene,biomaterials,electrospinning,neurite outgrowth,tissue engineering |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 27 Aug 2020 09:20 |
Last Modified: | 26 Nov 2024 00:47 |
Published Version: | https://doi.org/10.1002/adfm.202003710 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1002/adfm.202003710 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:164873 |