Parris, K.M. orcid.org/0000-0002-1382-5146, Amabebe, E. orcid.org/0000-0002-3924-5270, Cohen, M.C. et al. (1 more author) (2020) Placental microbial–metabolite profiles and inflammatory mechanisms associated with preterm birth. Journal of Clinical Pathology, 74 (1). pp. 10-18. ISSN 0021-9746
Abstract
There is growing emphasis on the potential significance of the placental microbiome and microbiome–metabolite interactions in immune responses and subsequent pregnancy outcome, especially in relation to preterm birth (PTB). This review discusses in detail the pathomechanisms of placental inflammatory responses and the resultant maternal–fetal allograft rejection in both microbial-induced and sterile conditions. It also highlights some potential placental-associated predictive markers of PTB for future investigation. The existence of a placental microbiome remains debatable. Therefore, an overview of our current understanding of the state and role of the placental microbiome (if it exists) and metabolome in human pregnancy is also provided. We critical evaluate the evidence for a placental microbiome, discuss its functional capacity through the elaborated metabolic products and also describe the consequent and more established fetomaternal inflammatory responses that stimulate the pathway to preterm premature rupture of membranes, preterm labour and spontaneous PTB.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The Author(s). This is an author-produced version of a paper subsequently published in Journal of Clinical Pathology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Preterm Birth; Placenta; Microbiome; Metabolite; Inflammation |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 20 Aug 2020 08:12 |
Last Modified: | 25 Jan 2022 10:30 |
Status: | Published |
Publisher: | BMJ Publishing Group |
Refereed: | Yes |
Identification Number: | 10.1136/jclinpath-2020-206536 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:164688 |