Wilson, DN, Hauryliuk, V, Atkinson, GC et al. (1 more author) (2020) Target protection as a key antibiotic resistance mechanism. Nature Reviews Microbiology, 18. pp. 637-648. ISSN 1740-1526
Abstract
Antibiotic resistance is mediated through several distinct mechanisms, most of which are relatively well understood and the clinical importance of which has long been recognized. Until very recently, neither of these statements was readily applicable to the class of resistance mechanism known as target protection, a phenomenon whereby a resistance protein physically associates with an antibiotic target to rescue it from antibiotic-mediated inhibition. In this Review, we summarize recent progress in understanding the nature and importance of target protection. In particular, we describe the molecular basis of the known target protection systems, emphasizing that target protection does not involve a single, uniform mechanism but is instead brought about in several mechanistically distinct ways.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Springer Nature Limited 2020. This is an author produced version of an article published in Nature Reviews Microbiology. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Aug 2020 13:11 |
Last Modified: | 05 Jul 2022 11:03 |
Status: | Published |
Publisher: | Nature Research |
Identification Number: | 10.1038/s41579-020-0386-z |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:164346 |