Ludewig, H, Molyneux, S, Ferrinho, S et al. (4 more authors) (2020) Halogenases: structures and functions. Current Opinion in Structural Biology, 65. pp. 51-60. ISSN 0959-440X
Abstract
Over 5000 halogenated natural products have been reported so far, many of these arising from the marine environment. The introduction of a halogen into a molecule can significantly impact its bioavailability and bioactivity. More recently enzymatic halogenation has been used to enable late stage functionalisation through site-selective halogenation and cross-coupling. Halogenases are becoming increasingly valued tools. This review outlines the various classes of halogenases that have been discovered, and examines these from both a structural and a mechanistic perspective, reflecting upon the many recent advances in halogenase discovery.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Halogenases; diverse structures mediating distinctive chemistries |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Mechanistic Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Aug 2020 14:10 |
Last Modified: | 13 Aug 2020 14:10 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.sbi.2020.05.012 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:164329 |