O’Gorman, P, Naimimohasses, S, Monaghan, A et al. (9 more authors) (2020) Improvement in histological endpoints of MAFLD following a 12-week aerobic exercise intervention. Alimentary Pharmacology & Therapeutics, 52 (8). pp. 1387-1398. ISSN 0269-2813
Abstract
Background
Lifestyle interventions are the primary treatment for metabolic (dysfunction) associated fatty liver disease (MAFLD). However, the histological and cardiometabolic effects of aerobic exercise in MAFLD remain unclear.
Aims
To assess the effects of a 12‐week aerobic exercise intervention on histological and cardiometabolic endpoints in MAFLD.
Methods
Patients with biopsy‐confirmed MAFLD participated in a 12‐week aerobic exercise intervention. Liver histology, cardiorespiratory fitness (estimated V̇O2max), physical activity, anthropometry and biochemical markers were assessed at baseline, intervention completion, and 12 and 52 weeks after intervention completion.
Results
Twenty‐four patients completed the exercise intervention (exercise group n = 16, control group n = 8). In the exercise group, 12 weeks of aerobic exercise reduced fibrosis and hepatocyte ballooning by one stage in 58% (P = 0.034) and 67% (P = 0.020) of patients, with no changes in steatosis (P = 1.000), lobular inflammation (P = 0.739) or NAFLD activity score (P = 0.172). Estimated V̇O2max increased by 17% compared to the control group (P = 0.027) but this level of improvement was not maintained at 12 or 52 weeks after the intervention. Patients with fibrosis and ballooning improvement increased estimated V̇O2max by 25% (P = 0.020) and 26% (P = 0.010), respectively. Anthropometric reductions including body mass (P = 0.038), waist circumference (P = 0.015) and fat mass (P = 0.007) were also observed, but no patient achieved 7%‐10% weight loss.
Conclusion
This study highlights the potential benefits of a 12‐week aerobic exercise intervention in improving histological endpoints of MAFLD. The development of strategies to ensure continued engagement in aerobic exercise in MAFLD are needed.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: O’Gorman, P, Naimimohasses, S, Monaghan, A, et al. Improvement in histological endpoints of MAFLD following a 12‐week aerobic exercise intervention. Aliment Pharmacol Ther. 2020; 00: 1– 12, which has been published in final form at https://doi.org/10.1111/apt.15989. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Nutrition and Public Health (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 17 Aug 2020 12:08 |
Last Modified: | 29 Mar 2023 01:44 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/apt.15989 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:164172 |
Commentary/Response Threads
- O’Gorman, P, Naimimohasses, S, Monaghan, A, Kennedy, M, Melo, AM, Ní Fhloinn, D, Doherty, DG, Beddy, P, Finn, SP, Moore, JB, Gormley, J and Norris, S Improvement in histological endpoints of MAFLD following a 12-week aerobic exercise intervention. (deposited 17 Aug 2020 12:08) [Currently Displayed]