Lee, M. orcid.org/0000-0001-9971-1635, Dimairo, M. orcid.org/0000-0002-9311-6920, Edwards, J. et al. (5 more authors) (2020) Non-randomised studies should be considered for assessing surgical techniques in rectal prolapse : prospective cohort study. Colorectal Disease, 22 (12). pp. 2170-2180. ISSN 1462-8910
Abstract
Objectives
Randomised trials comparing surgical techniques for rectal prolapse are not always feasible. We assessed whether non‐randomised comparisons of those who have had surgery with those still waiting would be confounded baseline health status.
Study Design and Setting
Prospective cohort study in seven UK hospitals. Participants ≥18 years listed for surgical interventions of equivalent intensity for rectal prolapse. Participants were defined as short or long waiters (≤ or >18 weeks, respectively). Time on the waiting list was compared with baseline comorbidity (Charlson Comorbidity Index, CCI) and change from baseline in health status (EQ‐5D‐5L) at the time of surgery.
Results
203 patients were analysed. Median (IQR) waiting time was 13.7 weeks (8.1, 20.4) varying across sites. Baseline comorbidity was not an important predictor of waiting time. Median CCI was 2 (0, 3) for short and 1 (0, 3) for long waiters. A change in waiting time by a week was associated with negligible improvement in EQ‐5D‐5L index of 0.001 (95%CI: ‐0.000 to 0.003, p =0.106).
Conclusion
Negligible change in patient reported health status while on waiting list and lack of effect of comorbidities in influencing waiting time supports the use of non‐randomised pre‐/post‐study to compare the effects of surgical interventions for rectal prolapse.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | Waiting list; comorbidity; health status; rectal prolapse; cohort study |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 07 Aug 2020 08:59 |
Last Modified: | 04 Feb 2022 15:55 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/codi.15293 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:164069 |