Karageorgis, G orcid.org/0000-0001-5088-6047, Liver, S and Nelson, A orcid.org/0000-0003-3886-363X (2020) Activity‐directed synthesis: A flexible approach for lead generation. ChemMedChem, 15 (19). pp. 1776-1782. ISSN 1860-7179
Abstract
Activity‐directed synthesis (ADS) is a structure‐blind, functional‐driven molecular discovery approach. In this Concept, four case studies highlight the general applicability of ADS and showcase its flexibility to support different medicinal chemistry strategies. ADS deliberately harnesses reactions with multiple possible outcomes, and allows many chemotypes to be evaluated in parallel. Resources are focused on bioactive molecules which emerge in tandem with associated synthetic routes. Some of the future challenges for ADS are highlighted, including the realisation of an autonomous molecular discovery platform. The prospects for ADS to become a mainstream lead generation approach are discussed.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Karageorgis, G , Liver, S and Nelson, A (2020) Activity‐directed synthesis: A flexible approach for lead generation. ChemMedChem, 15 (19). pp. 1776-1782. ISSN 1860-7179, which has been published in final form at https://doi.org/10.1002/cmdc.202000524 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: | lead generation; molecular diversity; reaction toolkit |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 03 Aug 2020 15:15 |
Last Modified: | 20 Jul 2022 11:07 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/cmdc.202000524 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:163934 |