Fazal, A, Webb, ME and Seipke, RF orcid.org/0000-0002-6156-8498 (2020) The Desotamide Family of Antibiotics. Antibiotics, 9 (8). 452. ISSN 2079-6382
Abstract
Microbial natural products underpin the majority of antimicrobial compounds in clinical use and the discovery of new effective antibacterial treatments is urgently required to combat growing antimicrobial resistance. Non-ribosomal peptides are a major class of natural products to which many notable antibiotics belong. Recently, a new family of non-ribosomal peptide antibiotics were discovered—the desotamide family. The desotamide family consists of desotamide, wollamide, surugamide, ulleungmycin and noursamycin/curacomycin, which are cyclic peptides ranging in size between six and ten amino acids in length. Their biosynthesis has attracted significant attention because their highly functionalised scaffolds are cyclised by a recently identified standalone cyclase. Here, we provide a concise review of the desotamide family of antibiotics with an emphasis on their biosynthesis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | natural products; non-ribosomal peptides; NRPS; standalone enzymes; cyclases |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) |
Funding Information: | Funder Grant number BBSRC (Biotechnology & Biological Sciences Research Council) BB/T008075/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 29 Jul 2020 11:40 |
Last Modified: | 25 Jun 2023 22:22 |
Status: | Published |
Publisher: | MDPI |
Identification Number: | 10.3390/antibiotics9080452 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:163827 |