Li, R, Adami, A, Chang, C-C et al. (3 more authors) (2020) Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD. Medicine & Science in Sports & Exercise. ISSN 0195-9131
Abstract
Purpose
Chronic obstructive pulmonary disease (COPD) is associated with altered metabolism and body composition that accompany poor outcomes. We aimed to determine whether metabolic derangements in COPD are associated with skeletal muscle deconditioning and/or physical inactivity, independent of pulmonary obstruction.
Methods
We characterized serum metabolites associated with muscle oxidative capacity or physical activity in 44 COPD patients (FEV1=61±4%predicted) and 63 current and former smokers with normal spirometry (CON) (FEV1=93±2%predicted). Medial gastrocnemius oxidative capacity was assessed at rest from the recovery rate constant (k) of muscle oxygen consumption using near-infrared spectroscopy. Step counts and physical activity (average vector magnitude units (VMU)/min) were measured over 5-7 days using triaxial accelerometry. Untargeted prime and lipid metabolites were measured using liquid chromatography and mass spectrometry.
Results
Muscle k (1.12±0.05 vs. 1.68±0.06min-1; P<0.0001; d=1.58) and VMU/min (170±26 vs. 450±50 VMU/min; P=0.004; d=1.04) were lower in severe COPD (FEV1<50%predicted, n=14-16) compared with CON (n=56-60). 129 prime metabolites and 470 lipids with known identity were quantified. Using sex as a covariate, lipidomics revealed 24 differentially expressed lipids (19 sphingomeylins) in COPD, consequent to a diminished sex difference of sphingomeylins in COPD (FDR<0.05; n=44). Total, and some individual, fatty acid concentrations were greater in severe COPD than CON (FDR<0.05; n=16; d=0.56-1.02). After adjusting for FEV1%predicted, we observed that grouped diacylglycerides (ρ=-0.745; FDR=0.03) and triacylglycerides (ρ=-0.811; FDR=0.01) were negatively associated with muscle oxidative capacity, but not physical activity, in severe COPD (n=14).
Conclusion
Strong negative associations relate impaired mitochondrial function to the accumulation of serum aclyglycerides in severe COPD.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 American College of Sports Medicine. This is an author produced version of "Li, R, Adami, A, Chang, C-C et al. (3 more authors) (2020) Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD. Medicine & Science in Sports & Exercise, http://doi.org/10.1249/mss.0000000000002441 published in Medicine and Science in Sports and Exercise ISSN 0195-9131. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Metabolomics; mitochondria; physical activity; sphingomyelin; fatty acid |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 Jul 2020 12:46 |
Last Modified: | 16 Jul 2021 00:38 |
Status: | Published online |
Publisher: | Wolters Kluwer Health |
Identification Number: | 10.1249/mss.0000000000002441 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:163620 |