Beevers, Z, Hussain, S, Boele, F orcid.org/0000-0003-0409-7949 et al. (1 more author) (2020) Pharmacological treatment of depression in people with a primary brain tumour. Cochrane Database of Systematic Reviews, 7 (7). CD006932. ISSN 1469-493X
Abstract
Background This is the second updated version of the Cochrane Review published in Issue 3, 2010 and first updated in Issue 5, 2013. People with a primary brain tumour oGen experience depression, for which drug treatment may be prescribed. However, they are also at high risk of epileptic seizures, cognitive impairment, and fatigue, all of which are potential adverse side effects of antidepressants. The benefit, or harm, of pharmacological treatment of depression in people with a primary brain tumour is unclear. Objectives To assess the benefits and harms of pharmacological treatment of depression in people with a primary brain tumour. Search methods We updated the search to include CENTRAL, MEDLINE, Embase, and PsycINFO to September 2019. As in the original review, we also handsearched Neuro-Oncology, Journal of Neuro-Oncology, Journal of Neurology, Neurosurgery and Psychiatry, and Journal of ClinicalOncology: for the current update we handsearched the latest three years of articles from these journals (up to November 2019). Selection criteria We searched for all randomised controlled trials (RCTs), controlled clinical trials, cohort studies, and case-control studies of any pharmacological treatment of depression in people with a histologically diagnosed primary brain tumour. Data collection and analysis No studies met the inclusion criteria. Main results We found no eligible studies evaluating the benefits of any pharmacological treatment of depression in people with a primary brain tumour. Authors' conclusions We identified no high-quality studies that investigated the value of pharmacological treatment of depression in people with a primary brain tumour. RCTs and detailed prospective studies are required to inform the effective pharmacological treatment of this common and important complication of brain tumours. Since the last version of this review none of the related new literature has provided additional information to change these conclusions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Copyright © 2019 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Reproduced in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) |
Funding Information: | Funder Grant number Yorkshire Cancer Research Not Known |
Depositing User: | Symplectic Publications |
Date Deposited: | 22 Jul 2020 13:01 |
Last Modified: | 22 Mar 2022 14:58 |
Status: | Published |
Publisher: | Wiley-Blackwell |
Identification Number: | 10.1002/14651858.CD006932.pub4 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:163549 |