Trindade, AF, Faulkner, EL, Leach, AG et al. (2 more authors) (2020) Fragment-oriented synthesis: β-elaboration of cyclic amine fragments using enecarbamates as platform intermediates. Chemical Communications. ISSN 1359-7345
Abstract
A strategy for the β-sp3 functionalisation of cyclic amines is described. Regioselective conversion of protected amines to enecarbamates is achieved through electrochemical oxidation; these intermediates can be derivatised by functionalised alkyl halides under photoredox catalysis. The potential of the methods is highlighted by direct growth of a DCP2B-binding fragment.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2020. Published open access under the terms of the CC-BY 3.0 licence: https://creativecommons.org/licenses/by/3.0/ |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 Jul 2020 11:25 |
Last Modified: | 25 Jun 2023 22:21 |
Status: | Published online |
Publisher: | Royal Society of Chemistry (RSC) |
Identification Number: | 10.1039/d0cc03934a |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:163229 |