Scalabrin, M, Adams, V, Labeit, S et al. (1 more author) (2020) Emerging Strategies Targeting Catabolic Muscle Stress Relief. International Journal of Molecular Sciences, 21 (13). 4681. ISSN 1661-6596
Abstract
Skeletal muscle wasting represents a common trait in many conditions, including aging, cancer, heart failure, immobilization, and critical illness. Loss of muscle mass leads to impaired functional mobility and severely impedes the quality of life. At present, exercise training remains the only proven treatment for muscle atrophy, yet many patients are too ill, frail, bedridden, or neurologically impaired to perform physical exertion. The development of novel therapeutic strategies that can be applied to an in vivo context and attenuate secondary myopathies represents an unmet medical need. This review discusses recent progress in understanding the molecular pathways involved in regulating skeletal muscle wasting with a focus on pro-catabolic factors, in particular, the ubiquitin-proteasome system and its activating muscle-specific E3 ligase RING-finger protein 1 (MuRF1). Mechanistic progress has provided the opportunity to design experimental therapeutic concepts that may affect the ubiquitin-proteasome system and prevent subsequent muscle wasting, with novel advances made in regards to nutritional supplements, nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) inhibitors, myostatin antibodies, β2 adrenergic agonists, and small-molecules interfering with MuRF1, which all emerge as a novel in vivo treatment strategies for muscle wasting.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | atrophy; diaphragm; disuse; mitochondria; MuRF1; MuRF2; skeletal muscle; ubiquitin; wasting |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Funding Information: | Funder Grant number MRC (Medical Research Council) MR/S025472/1 Heart Research UK RG2683/19/21 |
Depositing User: | Symplectic Publications |
Date Deposited: | 03 Jul 2020 12:22 |
Last Modified: | 25 Jun 2023 22:20 |
Status: | Published |
Publisher: | MDPI AG |
Identification Number: | 10.3390/ijms21134681 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:162725 |