Eriksen, EF, Shabestari, M, Ghouri, A orcid.org/0000-0003-2514-5022 et al. (1 more author) (2021) Bisphosphonates as a treatment modality in osteoarthritis. Bone, 143. 115352. ISSN 8756-3282
Abstract
Osteoarthritis (OA) is affecting large proportions of the population worldwide. So far, no effective disease modifying drug has been developed for this disease, limiting the therapeutic options to pain medications, physiotherapy and ultimately surgical approaches, mainly joint implant surgery. In vitro and animal studies have demonstrated that bisphosphonates have the potential to become effective modalities for the treatment of OA. This group of pharmacological agents modulates crucial aspects of OA pathogenesis (subchondral bone turnover and loss, bone marrow edema formation, cartilage degeneration and synovitis), and have shown clear efficacy in animal models of OA. Human studies have, however, so far been disappointing with only one of six clinical studies showing clear short-term efficacy. Possible reasons for these discrepancies will be discussed.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Published by Elsevier. All rights reserved. This is an author produced version of an article published in Bone. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Bisphosphonates; Osteoarthritis; Bone marrow lesions; Subchondral bone |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Musculoskeletal Medicine & Imaging (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 03 Jul 2020 11:19 |
Last Modified: | 13 Jan 2023 16:00 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.bone.2020.115352 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:162557 |