Walker, Matthew, Will, Iain Gordon, Pratt, Andrew orcid.org/0000-0002-0795-2640 et al. (3 more authors) (2020) Magnetically-Triggered Release of Entrapped Bioactive Proteins from Thermally Responsive Polymer-Coated Iron Oxide Nanoparticles for Stem Cell Proliferation. ACS Applied Nano Materials. pp. 5008-5013. ISSN 2574-0970
Abstract
Nanoparticles could conceal bioactive proteins during therapeutic delivery, avoiding side effects. Superparamagnetic iron oxide nanoparticles (SPIONs) coated with a temperature-sensitive polymer were tested for protein release. We show that coated SPIONs can entrap test proteins and release them in a temperature-controlled manner in a biological system. Magnetically heating SPIONs triggered protein release at bulk solution temperatures below polymer transition. The entrapped growth factor Wnt3a was inactive until magnetically-triggered release, upon which it could increase mesenchymal stem cell proliferation. Once chemically adjusting polymer transition above body temperature this system could be used for targeted cell stimulation in model animals and humans.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | superparamagnetic iron oxide nanoparticles; mesenchymal stem cells; in vivo protein delivery; temperature sensitive polymer; magnetic protein release; polymer coated nanoparticles |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Physics (York) |
Depositing User: | Pure (York) |
Date Deposited: | 26 Jun 2020 11:20 |
Last Modified: | 21 Jan 2025 17:47 |
Published Version: | https://doi.org/10.1021/acsanm.0c01167 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1021/acsanm.0c01167 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:162496 |