A core outcome set for pre‐eclampsia research : an international consensus development study

Abstract

Objective To develop a core outcome set for pre‐eclampsia.

Design Consensus development study.

Setting International.

Population Two hundred and eight‐one healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated.

Methods Modified Delphi method and Modified Nominal Group Technique.

Results A long‐list of 116 potential core outcomes was developed by combining the outcomes reported in 79 pre‐eclampsia trials with those derived from thematic analysis of 30 in‐depth interviews of women with lived experience of pre‐eclampsia. Forty‐seven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, small‐for‐gestational‐age, neonatal mortality, seizures, admission to neonatal unit required and respiratory support.

Conclusions The core outcome set for pre‐eclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies.

Metadata

Item Type:	Article
Authors/Creators:	Duffy, JMN Cairns, AE Richards‐Doran, D van 't Hooft, J Gale, C Brown, M Chappell, LC Grobman, WA Fitzpatrick, R Karumanchi, SA Khalil, A Lucas, DN Magee, LA Mol, BW Stark, M Thangaratinam, S Wilson, MJ https://orcid.org/0000-0002-9704-5189 von Dadelszen, P Williamson, PR Ziebland, S McManus, RJ Abalos, EJ Adamson, CCD Akadri, AA Akturk, Z Allegaert, K Angel‐Müller, E Antretter, J Audibert, F Auger, N Aygun, C Babic, I Bagga, R Baker, JM Bhandari, V Bhattacharya, S Blanker, MH Bloomfield, FH Bof, A Brennan, SM Broekhuijsen, K Fiona Broughton Pipkin, E Browne, JL Browning, RM Bull, JW Butt, A Button, D Campbell, JP Campbell, DM Carbillon, L Carthy, S Casely, E Cave, JA Cecatti, JG Chamillard, ME Chassard, D Checheir, NC Chulkov, VS Cluver, CA Crawford, CF Daly, MC Darmochwal‐Kolarz, DA Davies, RE Davies, MW Dawson, JS Dobson, N Dodd, CN Donald, F Duley, L Epstein‐Mares, J Erez, O Evans, E Farlie, RN Ferris, AV Frankland, EM Freeman, DJ Gainder, S Ganzevoort, W Gbinigie, OA Ghosh, SK Glogowska, M Goodlife, A Gough, KL Green, JR Gul, F Haggerty, L Hall, DR Hallman, M Hammond, SJ Harlow, SD Hays, KE Hickey, SC Higgins, M Hinton, L Hobson, SR Hogg, MJ Hollands, HJ Homer, CSE Hoodbhoy, Z Howell, P Huppertz, B Husain, S Jacoby, SD Jacqz‐Aigrain, E Jenkins, G Jewel, D Johnson, MJ Johnston, CL Jones, PM Kantrowitz‐Gordon, I Khan, R Kirby, LJ Kirk, C Knight, M Korey, MT Lee, GJ Lee, VW Levene, LS Londero, AP Lust, KM MacKenzie, V Malha, L Mattone, M McCartney, DE McFadden, A McKinstry, BH Middleton, PF Mistry, HD Mitchell, CA Mockler, JC Molsher, S Monast, ES Moodley, J Mooij, R Moore, EL Morgan, L Moulson, A Mughal, F Mundle, SR Angel Munoz, M Murray, E Nagata, C Nair, AS Nakimuli, A Nath, G Newport, RS Oakeshott, P Ochoa‐Ferraro, MR Odendaal, H Ohkuchi, A Oliveira, L Ortiz‐Panozo, E Oudijk, MA Oygucu, SE Paech, MJ Painter, RC Parry, CL Payne, BA Pearson, EL Phupong, V Pickett, N Pickles, KA Plumb, LK Prefumo, F Preston, R Ray, JG Rayment, J Regan, LV Rey, E Robson, EJ Rubin, AN Rubio‐Romero, JA Rull, K Sass, N Sauvé, N Savory, NA Scott, JR Seaton, SE Seed, PT Shakespeare, JM Shand, AW Sharma, S Shaw, TY Smedley, KL Smith, D Smith Conk, A Soward, D Stepan, H Stroumpoulis, K Surendran, A Takeda, S Tan, L Theriot, BS Thomas, HF Thompson, K Thompson, PI Thompson, MJ Torney, KLHT Treadwell, JS Tucker, KL Turrentine, MA Van Hecke, O Van Oostwaard, MF Vasquez, DN Vaughan, DJA VInturache, A Walker, J Wardle, SP Wasim, T Waters, JH Whitehead, CL Wolfson, A Yeo, S Zermansky, AG
Copyright, Publisher and Additional Information:	© 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/
Keywords:	Consensus development study; core outcome set; modified Delphi method; modified nominal group technique; outcome reporting bias; pre‐eclampsia
Dates:	Accepted: 11 May 2020 Published (online): 21 June 2020 Published: 9 October 2020
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research
Depositing User:	Symplectic Sheffield
Date Deposited:	24 Jun 2020 12:27
Last Modified:	24 May 2022 10:16
Status:	Published
Publisher:	Wiley
Refereed:	Yes
Identification Number:	10.1111/1471-0528.16319
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:162319

Download

Published Version

Filename: 1471-0528.16319.pdf

Licence: CC-BY 4.0

CLICK TO DOWNLOAD

CORE (COnnecting REpositories)

A core outcome set for pre‐eclampsia research : an international consensus development study

Abstract

Metadata

Download

Published Version

Export

Statistics