Chhatwal, AR, Lomax, HV, Blacker, AJ orcid.org/0000-0003-4898-2712 et al. (2 more authors) (2020) Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO₃)₂ or imidazole as catalysts. Chemical Science, 11 (22). pp. 5808-5818. ISSN 2041-6520
Abstract
A new method for the direct synthesis of primary and secondary amides from carboxylic acids is described using Mg(NO3)2·6H2O or imidazole as a low-cost and readily available catalyst, and urea as a stable, and easy to manipulate nitrogen source. This methodology is particularly useful for the direct synthesis of primary and methyl amides avoiding the use of ammonia and methylamine gas which can be tedious to manipulate. Furthermore, the transformation does not require the employment of coupling or activating agents which are commonly required.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2020. This is an open access article under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) (https://creativecommons.org/licenses/by/3.0/) |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 Jun 2020 15:14 |
Last Modified: | 25 Jun 2023 22:18 |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/d0sc01317j |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:161916 |