Giovannelli, I., Heath, P., Shaw, P.J. orcid.org/0000-0002-8925-2567 et al. (1 more author) (2020) The involvement of regulatory T cells in amyotrophic lateral sclerosis and their therapeutic potential. Amyotrophic lateral sclerosis & frontotemporal degeneration, 21 (5-6). pp. 435-444. ISSN 2167-9223
Abstract
Neuroinflammation, meaning the establishment of a diffuse inflammatory condition in the CNS, is one of the main hallmarks of amyotrophic lateral sclerosis (ALS). Recently, a crucial role of regulatory T cells (Tregs) in this disease has been outlined. Tregs are a T cell subpopulation with immunomodulatory properties. In this review, we discuss the physiology of Tregs and their role in ALS disease onset and progression. Evidence has demonstrated that in ALS patients Tregs are dramatically and progressively reduced in number and are less effective in promoting immune suppression. In addition, Tregs levels correlate with the rate of disease progression and patient survival. For this reason, Tregs are now considered a promising therapeutic target for neuroprotection in ALS. In this review, the clinical impact of these cells will be discussed and an overview of the current clinical trials targeting Tregs is also provided.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases. This is an author-produced version of a paper subsequently published in Amyotrophic lateral sclerosis & frontotemporal degeneration. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Amyotrophic lateral sclerosis; clinical trials; neuroimmunology; neuroinflammation; regulatory T cells |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number EUROPEAN COMMISSION - HORIZON 2020 633413 MY NAME'5 DODDIE FOUNDATION UNSPECIFIED |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 11 Jun 2020 12:58 |
Last Modified: | 11 Nov 2021 16:41 |
Status: | Published |
Publisher: | Taylor & Francis |
Refereed: | Yes |
Identification Number: | 10.1080/21678421.2020.1752246 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:161821 |