Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions

Abstract

Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society For Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase-wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies and viral therapies will be reviewed, as well as the current challenges and future directions for research.

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Item Type:	Article
Authors/Creators:	This paper has 40 authors. You can scroll the list below to see them all or them all. Wen, PY Weller, M Lee, EQ Alexander, BA Barnholtz-Sloan, JS Barthel, FP Batchelor, TT Bindra, RS Chang, SM Chiocca, EA Cloughesy, TF DeGroot, JF Galanis, E Gilbert, MR Hegi, ME Horbinski, C Huang, RY Lassman, AB Le Rhun, E Lim, M Mehta, MP Mellinghoff, IK Minniti, G Nathanson, D Platten, M Preusser, M Roth, P Sanson, M Schiff, D Short, SC https://orcid.org/0000-0003-4423-7256 Taphoorn, MJB Tonn, J-C Tsang, J Verhaak, RGW von Deimling, A Wick, W Zadeh, G Reardon, DA Aldape, KD van den Bent, MJ
Copyright, Publisher and Additional Information:	© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. This is an author produced version of an article published in Neuro-Oncology. Uploaded in accordance with the publisher's self-archiving policy.
Dates:	Published (online): 24 April 2020
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	08 Jun 2020 12:47
Last Modified:	24 Apr 2021 00:38
Status:	Published online
Publisher:	Oxford University Press
Identification Number:	10.1093/neuonc/noaa106
Related URLs:	PubMed URL
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:161646

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Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions

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