Alsubhe, E, Anastasiou, AD, Mehrabi, M et al. (4 more authors) (2020) Analysis of the osteogenic and mechanical characteristics of iron (Fe2+/Fe3+)-doped β‑calcium pyrophosphate. Materials Science and Engineering: C, 115. 111053. ISSN 0928-4931
Abstract
The calcium phosphate is the main mineral constituent of bone. Although there has been significant amount of research on finding ideal synthetic bone, no suitable scaffold material has yet been found. In this investigation, the iron doped brushite (CaHPO4·2H2O) has been investigated for osteogenic potential and mechanical properties. The synthesis of iron-oxide doping in the form of Fe2+,3+-ions were carried out using the solution based method in which the ammonium hydrogen phosphate and calcium nitrate solutions were used in stoichiometric ratio for synthesizing CaHPO4·2H2O, with doping concentrations of Fe2+,3+-ions between 5 mol% and 30 mol%. The synthesized powders were analysed using X-ray powder diffraction, FTIR, SEM and Raman spectroscopic techniques. The heat treatment of synthesized powder was carried out at 1000 °C in air for 5 h, and it was found that the dominant crystalline phase in samples with <20 mol% was β-CPP, which also formed an iron-rich solid solution phase. Increasing the concentrations of Fe2+,3+-ions enhances the phase fraction of FePO4 and amorphous phase. Amongst the Fe2+,3+-doped β-CPP minerals, it was found that the 10 mol% Fe2+,3+-doped β-CPP offers the best combination of bio-mechanical and osteogenic properties as a scaffold for bone tissue regenerative engineering.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/). |
Keywords: | Brushite; β‑calcium pyrophosphate; Iron phosphate; Mechanical properties; Osteogenic cells |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) |
Funding Information: | Funder Grant number EU - European Union 752297 |
Depositing User: | Symplectic Publications |
Date Deposited: | 02 Jun 2020 14:13 |
Last Modified: | 24 Oct 2024 14:03 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.msec.2020.111053 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:161419 |