Russo, G., Pappalardo, F., Juarez, M.A. orcid.org/0000-0002-5128-0976 et al. (5 more authors) (2020) Evaluation of the efficacy of RUTI and ID93/GLA-SE vaccines in tuberculosis treatment : in silico trial through UISS-TB simulator. In: 2019 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 18-21 Nov 2019, San Diego, CA, USA.
Abstract
Tuberculosis (TB) is one of the deadliest diseases worldwide, with 1,5 million fatalities every year along with potential devastating effects on society, families and individuals. To address this alarming burden, vaccines can play a fundamental role, even though to date no fully effective TB vaccine really exists. Current treatments involve several combinations of antibiotics administered to TB patients for up to two years, leading often to financial issues and reduced therapy adherence. Along with this, the development and spread of drug-resistant TB strains is another big complicating matter. Faced with these challenges, there is an urgent need to explore new vaccination strategies in order to boost immunity against tuberculosis and shorten the duration of treatment. Computational modeling represents an extraordinary way to simulate and predict the outcome of vaccination strategies, speeding up the arduous process of vaccine pipeline development and relative time to market. Here, we present EU - funded STriTuVaD project computational platform able to predict the artificial immunity induced by RUTI and ID93/GLA-SE, two specific tuberculosis vaccines. Such an in silico trial will be validated through a phase 2b clinical trial. Moreover, STriTuVaD computational framework is able to inform of the reasons for failure should the vaccinations strategies against M. tuberculosis under testing found not efficient, which will suggest possible improvements.
Metadata
Item Type: | Conference or Workshop Item |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 IEEE. |
Keywords: | Tuberculosis; vaccine; in silico clinical trials; simulation |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Mathematics and Statistics (Sheffield) |
Funding Information: | Funder Grant number European Commission - Horizon 2020 777123 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 28 May 2020 13:18 |
Last Modified: | 28 May 2020 13:20 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1109/BIBM47256.2019.8983060 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:161336 |