Brooks, R., Williamson, R. and Bass, M. orcid.org/0000-0002-8854-9705 (2012) Syndecan-4 independently regulates multiple small GTPases to promote fibroblast migration during wound healing. Small GTPases, 3 (2). pp. 73-79. ISSN 2154-1248
Abstract
Upon wounding, syndecan-4 detects the appearance of fibronectin in the wound bed and mediates regulation of the small GTPases, Rac1, RhoA and RhoG. Cohesive regulation of these molecules results in cycles of membrane protrusion and cytoskeletal contraction, and triggers the endocytosis of α 5β 1-integrin, which collectively lead to immigration of fibroblasts into the wound bed. In this manuscript we identify the regulation of a fourth GTPase, Arf6 that is responsible for α 5β 1-integrin recycling and thereby completes the cycle of syndecan-4-regulated integrin trafficking. We demonstrate that each of the GTPase signals can be regulated by syndecan-4, but that they are independent of one another. By doing so we identify syndecan-4 as the coordinating center of pro-migratory signals.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2012 Landes Bioscience. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License (http://creativecommons.org/licenses/by/3.0). The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
Keywords: | ADP-Ribosylation Factors; Animals; Cell Line; Cell Movement; Fibroblasts; Integrin alpha5beta1; Mice; Signal Transduction; Syndecan-4; Wound Healing |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 26 May 2020 11:24 |
Last Modified: | 26 May 2020 11:24 |
Status: | Published |
Publisher: | Taylor & Francis |
Refereed: | Yes |
Identification Number: | 10.4161/sgtp.19301 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:161192 |