Liu, M, Liu, Z, Zhu, H et al. (2 more authors) (2020) Enantioseparation of racemic amlodipine using immobilized ionic liquid by solid‐phase extraction. Chirality, 32 (8). pp. 1062-1071. ISSN 0899-0042
Abstract
In this paper, a novel L‐glutamate based immobilized chiral ionic liquid (SBA‐IL (Glu)) was prepared by chemical bonding method and applied as a solid sorbent for chiral separation of amlodipine. The performance of SBA‐IL (Glu) was investigated for the absorption of (S)‐amlodipine and separation of amlodipine enantiomer. The static experiment showed that equilibrium adsorption was achieved within 80 minutes, and the saturation adsorptions capacity was 12 mg/g. The complex was then packed in a glass chromatographic column for the separation of amlodipine and the enantiomeric excess (%ee) of (S)‐amlodipine reached 24.67%. The immobilized ionic liquids exhibit good reusability, and the separation efficiency remains 18.24% after reused five times, which allows potential scale‐up for the chiral separation of amlodipine.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Wiley Periodicals LLC. This is the peer reviewed version of the following article: Liu, M, Liu, Z, Zhu, H et al. (2 more authors) (2020) Enantioseparation of racemic amlodipine using immobilized ionic liquid by solid‐phase extraction. Chirality, 32 (8). pp. 1062-1071. ISSN 0899-0042, which has been published in final form at: https://doi.org/10.1002/chir.23231. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: | amlodipine; enantioseparation; immobilized amino ionic liquid; solid‐phase extraction |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 May 2020 13:26 |
Last Modified: | 19 Jul 2022 11:36 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/chir.23231 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:160408 |